Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
نویسندگان
چکیده
منابع مشابه
Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.
3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, including protein kinase B (PKB)/Akt. Both PDK1 and PKB contain pleckstrin homology (PH) domains that interact with the PtdIns(3,4,5)P(3) second messenger. Dis...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2005
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn1524